Indomethacin Guide: Uses, Dosage, Side Effects & Safety Tips
If you’ve been prescribed indomethacin, you’re probably wondering what it does and how to use it safely. In plain terms, indomethacin is a strong anti‑inflammatory drug that helps reduce pain, swelling, and fever. It belongs to the NSAID family, the same group that includes ibuprofen and naproxen, but it’s generally reserved for tougher cases like arthritis, gout, or certain types of headache.
Most people take indomethacin as a tablet, but it also comes in a capsule, a liquid, and even a suppository for those who can’t swallow pills. The usual adult dose for pain or inflammation is 25–50 mg two or three times a day, but your doctor may adjust it based on your condition and how you respond. Never crank up the dose on your own – higher amounts increase the risk of stomach irritation and other side effects.
How Indomethacin Works
Indomethacin blocks the enzyme COX‑1 and COX‑2, which are responsible for making prostaglandins. Prostaglandins are chemicals that cause pain, swelling, and fever. By stopping their production, indomethacin eases those uncomfortable symptoms. This action is why it’s effective for conditions that involve joint inflammation, like rheumatoid arthritis, and for acute gout attacks.
Because it’s a potent NSAID, indomethacin can also affect other parts of the body. It may thin your blood a bit, which can be useful for preventing clots but also means you should be careful if you’re planning surgery or have a bleeding disorder. It also works on the kidneys, so people with kidney problems need a lower dose or may be advised to avoid it altogether.
Tips for Safe Use
Start by taking indomethacin with food or milk. This simple step can protect your stomach lining from irritation, which is one of the most common complaints. If you notice stomach pain, heartburn, or black stools, call your doctor right away – those could be signs of a more serious issue.
Stay hydrated. Drinking plenty of water helps your kidneys clear the drug and reduces the chance of kidney strain. If you’re on other meds, double‑check with a pharmacist or doctor. Indomethacin can interact with blood thinners, certain antidepressants, and other NSAIDs, which could raise the risk of bleeding or other problems.
Don’t mix indomethacin with alcohol. Alcohol can worsen stomach irritation and increase the chance of liver problems. If you’re a heavy drinker, talk to your healthcare provider about alternatives.
Lastly, keep track of how you feel. Most side effects, like mild nausea or dizziness, fade after a few days. But if you experience severe headaches, vision changes, or swelling in your legs, those could be signs of rare but serious reactions, and you should seek medical help promptly.
In short, indomethacin is a powerful tool for tackling tough inflammation, but it needs to be used responsibly. Follow your doctor’s instructions, watch for side effects, and stay in touch with your healthcare team if anything feels off. With the right approach, you can get the relief you need without unnecessary risks.
June 21, 2025
Alyssa Penford
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