Deflazacort: What It Is and Why Doctors Prescribe It
If you’ve seen the name deflazacort on a prescription bottle, you might wonder what it actually does. In plain terms, deflazacort is a synthetic steroid that reduces inflammation and suppresses the immune system. Doctors often choose it for conditions where long‑term steroid use is needed but they want a drug that may cause fewer weight‑gain or bone‑loss issues compared to other steroids.
One of the most common reasons patients get deflazacort is Duchenne muscular dystrophy (DMD). In DMD, the drug can slow muscle weakening and help kids stay stronger for longer. It’s also used for rheumatoid arthritis, asthma flare‑ups, and certain skin disorders when a strong anti‑inflammatory is required.
How to Take Deflazacort Safely
Deflazacort comes as a tablet, and the dose depends on the condition, the patient’s weight, and how they respond. For DMD, doctors usually start with a low dose (around 0.9 mg per kilogram of body weight per day) and adjust as needed. For arthritis, the dose might be lower, like 5‑10 mg daily. Always follow the exact instructions on the label or from your doctor—don’t guess or change the amount on your own.
Take the pill with food or a glass of milk if your stomach feels upset. Swallow it whole; crushing or chewing can affect how the drug works. If you miss a dose, take it as soon as you remember, but don’t double‑up later in the day.
Common Side Effects and What to Watch For
Like any steroid, deflazacort can cause side effects. The most frequent ones are mild and include increased appetite, weight gain, and trouble sleeping. Some people notice mood swings or a feeling of “butterflies” in the stomach.
More serious issues can appear with long‑term use. Keep an eye on bone health—deflazacort can lead to weaker bones, so calcium and vitamin D supplements may be recommended. Watch for signs of infection, such as fever or persistent cough, because the drug lowers your immune response.
If you notice severe swelling in your legs, sudden vision changes, or extreme mood changes, call your doctor right away. Blood tests may be needed periodically to check blood sugar, electrolytes, and liver function.
Because deflazacort can affect blood sugar, people with diabetes should monitor their levels closely and discuss dose adjustments with their healthcare provider.
Overall, the key to using deflazacort safely is regular check‑ups, honest communication with your doctor, and not stopping the medication abruptly. If you need to stop, your doctor will likely taper the dose over weeks to avoid withdrawal symptoms.
Deflazacort isn’t a one‑size‑fits‑all drug, but for many patients it offers a balance between strong anti‑inflammatory action and a somewhat milder side‑effect profile than older steroids. Talk to your doctor about whether it’s the right choice for you, and keep these practical tips in mind to get the most benefit while minimizing risks.
August 16, 2025
Alyssa Penford
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Clear 2025 UK guide to Calcort (deflazacort): what it’s for, how to take it, dose equivalents, tapering, side effects, and safety tips. People-first and practical.
