Leukeran (Chlorambucil) Guide – Uses, Dosage, Side Effects & Safety

When is Leukeran prescribed?

Leukeran is most often given to people with chronic lymphocytic leukemia (CLL) and some types of non‑Hodgkin lymphoma. It works by interfering with DNA inside cancer cells, slowing their growth. Doctors may also consider it for autoimmune disorders when other treatments fail, but that’s less common. If you have a diagnosis of CLL, your oncologist will look at your disease stage, overall health, and blood counts before deciding whether Leukeran fits your plan.

How to take Leukeran safely

Leukeran comes in tablet form, usually 2 mg or 6 mg. The typical starting dose for CLL is 0.1 mg/kg per day, taken once a day with a full glass of water. Some doctors prefer a “pulse” schedule – a few days on, a few days off – to reduce side effects. Never split a tablet unless your pharmacist says it’s okay; the coating controls how the drug is released.

Take the dose at the same time each day. If you miss a dose, take it as soon as you remember, unless it’s almost time for the next one – then skip the missed one. Doubling up can increase toxicity. Keep a medication diary; noting the date, dose, and any symptoms helps your doctor spot problems early.

Before you start, your doctor will run blood tests to check kidney and liver function. Regular monitoring (usually every 2–4 weeks) tracks white‑blood‑cell counts, because Leukeran can suppress bone‑marrow activity. If counts drop too low, the doctor may pause treatment or lower the dose.

Common side effects include nausea, vomiting, loss of appetite, and mild hair thinning. The big one to watch for is a drop in blood cells, which can lead to infections, anemia, or easy bruising. If you develop a fever, sore throat, or unusual bruising, call your healthcare team right away.

Long‑term use may raise the risk of secondary cancers, especially skin cancers. Protect yourself with sunscreen, wear protective clothing, and get regular skin checks. Staying hydrated, eating a balanced diet, and avoiding alcohol can also help your body handle the drug better.

When you need to buy Leukeran, only use licensed pharmacies that require a valid prescription. In the UK, online pharmacies must be registered with the MHRA and show a clear address and contact details. Look for “Registered Pharmacy” logos and read customer reviews for reliability. Never buy from sites that offer the drug without a prescription – counterfeit versions can be dangerous.

If cost is a concern, ask your doctor about patient assistance programs or generic alternatives. Some charities and NHS schemes help cover chemotherapy expenses, especially for long‑term treatments.

Bottom line: Leukeran can be an effective option for specific blood cancers when taken exactly as prescribed and monitored closely. Keep open communication with your medical team, track side effects, and use reputable sources for any refills. With the right precautions, you can manage the treatment while minimizing risks.